0050 Pediatric OSA and neurodevelopment

Abstract Introduction Pediatric OSA and its associated sleep disorders occur in up to 7% of children. Whereas the sequelae disease are well characterized, underpinnings phenotypes poorly understood. This is mainly because a lack comprehensive model young. Here I present neurobehavioral phenotype pediatric utilizing preclinical murine model. Methods proposal represents departure from prior models embedded sculpting IH 1) Human polysomnographic data: We studied human data children with 2) Murine oximetry we create curves 3) Cross Species Curve Fitting: cross fit those across species 4) Optimization hypoxic gas throughputs: then optimized this for hypoxia chamber using Results examined 4 behavioral tasks over number time periods establish temporality needed hippocampal task ablation, as hippocampus center learning memory mammals. 2 were dependent: a) Novel object recognition b) Object place recognition. independent: Hot plate: OFA. utilized 3 initially: exposure p14 p23 (9 days acute), p35 (21 intermediate), p70 (56 days, chronic). There was no deterioration p35, however at noted ablation. therefore systematically worked backwards, until discovered 'tipping point' where ablation observed p49 (35 exposure). Prior this, note after point, preserved. Conclusion have demonstrated tractable, temporal systematic set points show when deficits stimulus manifest phenotypically. further isolated these developing mice, which mammalian learning, memory, retrieval. Support (if any) Arvind has previously received support AASM BCM OOR. He currently supported by 1K08HL161263-01 NHLBI.